I'd go with the exact same top 3 lines, although I doubt Babcock will.
Abdelkader is missing and he'll definitely be in the line-up, Weiss will too if he gets healthy. Ferraro will definitely be back in Grand Rapids, and its likely Jurco will too If everyone is back from injury.
Fully healthy I think the best we can hope for from Babcock is something along the lines of
Zetterberg - Datsyuk - Alfredsson
Nyquist - Legwand - Franzen
Tatar - Weiss - Sheahan
Abdelkader - Helm - Miller
scratches - Glendening, Bert. Andersson
Kronwall - Ericsson
Dekeyser - Quincey
Lashoff - Smith
This would be ideal for me. I'd even be up for making the kid line the third line when Jurco comes back and sitting Weiss. At this point, he's almost gone two full seasons without playing a significant amount. I really wonder about his future with the team. From what we've seen with Legwand, I wouldn't mind seeing Weiss bought out this summer.
Barring we make the playoffs, the only wildcard would be Cleary. If healthy, I could see him reinserted back in the lineup due to the gritty/veteran presence in the playoffs mentality. I haven't seen any news about his injury recently, however.