It's not like these draft picks are the equivalent of taking Stefan #1 in 1999 or Daigle #1 in 1993 or even taking Hugh Jessiman #12 in 2003.
Quincey was a really solid 4th round pick, but yes... trading the 2012 1st to get him back when they should've just waived Derek Meech instead of Quincey years before was a mistake to cover a mistake.
The others, though? Sure, they could've drafted P.K. instead of Smith. But, there were 6 or 7 D-men drafted between Smith and Subban. Odds are, if they didn't draft Smith, they would've ended up with someone worse and wouldn't now have Zachary Gallant and Jared McIsaac.
Sure, they could've had Tuukka Rask instead of Kindl. But, they took Howard with their 1st draft pick 2 years before. No way they were going to take another goalie that high so soon. Yeah, there are other better players drafted after Kindl that year but not many D and none besides Rask who would've significantly moved the needle for the franchise enough to cry about it.
Sheahan? Yeah, Hayes or Kuznetsov would've been better in hindsight. But, again, how big of difference would they really have made for Detroit? The playoff streak gets extended another year?
If I'm really looking for picks to complain about (and I'm not - it has to be so ridiculously hard to predict how these kids will turn out)... I'm going with having 3 2nd rounders in 2011, ending up whiffing on all 3 and Kucherov was right there the whole time.